AI Hits the White House, the Courtroom & the Enterprise Stack

A federal judge just told OpenAI it can’t use a dictionary word, Anthropic shipped a model that can out-code half your engineering team, and the White House quietly launched a “Genesis Mission” that sounds suspiciously like a Manhattan Project for AI-powered science.

Jeff and Annie break down a moment where law, policy, economics, and frontier AI all collide. They unpack Cameo’s surprise win against OpenAI over the word “cameo,” Anthropic’s Claude 4.5 Opus and what it means for junior devs and middle managers, and the escalating AI shopping war as ChatGPT and Perplexity take aim at Google’s core business.

Then they zoom out: the White House’s national AI infrastructure play, new Anthropic + MIT data on AI’s impact on GDP and automation, and Andrej Karpathy’s argument that AI detection is dead, forcing schools back toward blue books, oral exams, and new ways to measure what students actually know.

In this episode, we cover:

• Trademark chaos: Why a fight over the word “cameo” could reshape how AI features are named — and defended.
• Agentic engineering: How Claude 4.5 Opus moves automation from “help me debug” to “ship production-ready fixes.”
• National AI strategy: What the Genesis Mission, AI shopping agents, and new economic studies reveal about the future of GDP, jobs, and education.

• Judge blocks OpenAI from using “Cameo” in Sora
• Anthropic releases Claude 4.5 Opus, new coding SOTA
• ChatGPT launches Shopping Research, challenges Google
• White House announces Genesis Mission for AI science
• Anthropic study on workflow automation potential
• MIT macro study modeling AI-driven GDP growth
• Karpathy says AI detection is impossible